Figure 1: Schematic diagram of possible interactions of immune effector molecules in the joint after antibody transfer. IC, immune complex; N, neutrophils; M , macrophages; M, mast cells; C1q, C3, C3a, C5a, and B, complement components; FcγR, Fcγ receptor; IL-1, interleukin 1; TNF, tumor necrosis factor; TGF, transforming growth factor; LTB4, leukotriene B4; MIP-1α, macrophage inflammatory protein
From: Nandakumar KS, Svensson L, Holmdahl R. Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol. 2003 Nov;163(5):1827-37