Bacterial pulmonary infections are a major problem in immunocompromised patients. Due to increasing emergence of antibiotic resistance the need to discover new antimicrobial therapeutics increases drastically.
At Fraunhofer ITEM, mouse models of bacterial pulmonary infection are established e.g. for S. aureus (acute) and P. aeruginosa (chronic). In acute infection models, main read outs are health score/ survival, bacterial load in lung and peripheral tissues, inflammatory cell counts. In chronic infection model, the health score, inflammatory response and particularly persistence of the pathogen are main readouts.