The Isolated Perfused Rat Lung (IPL) model simulates whole organ exposure to inhalable or i.v.-administered substances. Test substances can originate from any source (medication, chemicals, environmental pollutants, etc.). Aerosol generation can be done from solid or liquid material and is conducted with extrapolation to the model lung.
The model allows constant blood gas analysis and data acquisition of common respiratory parameters (TV, Resistance, Cdyn). IPL data can be used to assess acute inhalation toxicity, substance kinetics or administration efficacy.