Figure 1: Assessment of neuropathic pain symptoms and histopathology after SNL (=L5T) surgery (from: Leichsenring et al., 2008).
A+B: Time course of neuropathic mechanical allodynia in the ipsilateral hind paw expressed as ipsilateral threshold (A) and Diffscore (B, difference between contralateral and ipsilateral withdrawal threshold) in L5T and sham operated (= surgery without nerve injury) animals. The L5T lesion led to a pronounced mechanical allodynia for up to 28 days.
C+D: Representative example of ED1-immunostained proximal stump of transected spinal nerve at 14 days after injury. The whole stump is densely filled with ED1-immunopositive macrophages (C) aligning along the trajectory of the axons (D). hab, habituation. Scale bars, 200 μm (C) and 20 μm (D).