Figure 1: Clinical symptoms of PIA in rats.
A: Clinical score in saline (black squares) and methotrexate (MTX; open triangles) treated rats after PIA induction.
B: Percentages of animals treated with saline or MTX developing a chronic form of the disease. MTX significantly reduces the number of animals suffering from the chronic form of the disease.
C: Hind paws of a healthy rat (left) and a rat with acute PIA (right).