HRV is the most common pathogen to induce respiratory infection in adults leading not only to simple common cold but also to severe exacerbations in patients with chronic lung disease (e.g. asthma).
Precision-cut lung slices, which are viable lung slices generated e.g. from human lung, are an ex vivo organotypic tissue model which is valuable as translational model bridging the gap between experimental animal research and clinical application. PCLS are used to study a wide range of endpoints e.g. cytotoxicity, cytokine release, bronchoconstriction.
We are currently developing a viral infection model in human and mouse PCLS using HRV, which aims to evaluate viral infection and anti-viral immune response particularly with aim of species comparison.