HRV and RSV are the most common pathogens to induce respiratory viral infection in humans, resulting not only in simple common cold but also to severe illness (e.g. RSV in children) and exacerbations in patients with chronic lung disease (e.g. asthma).
We have established a mouse model of respiratory infection for HRV1b and RSV with infection via intranasal inoculation. The induced mild viral infection leads to respiratory neutrophilic infection and inflammation and the induction of the anti-viral host response. These models are a valuable tool to study e.g. the efficacy of anti-viral or immunomodulatory compounds.